All the great questions of life boil down to this: What is the best way to live?
The great questions of life include the ones that Socrates posed 2400 year ago: what is courage? what is moderation? what is justice? what is love? what is beauty? what is truth? what is wisdom?
The great questions also include more modern concerns, such as how best to make a living, to find one's calling, or to interact with technology (topics that much exercised Thoreau, for instance).
I suppose that some people don't think about the great questions - instead they skate or slouch or sleepwalk through life, unaware of the deeper themes of human existence.
Others are certain that the great questions have straightforward answers, inherited from a particular creed or religion or cultural tradition.
Socrates often undercut such people's certainty by haranguing them in the Athenian agora. Eventually they got tired of him and put him to death. Yet Socrates had the last laugh: no one remembers his accusers, but they do remember his admonition that the unexamined life is not worth living for a human being. In more positive terms we could phrase it like this: "The best way to live is to never stop asking yourself: What is the best way to live?"
(Cross-posted at philosopher.coach.)